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Indications

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone. Read More

ENBREL is indicated for chronic moderate to severe plaque psoriasis (PsO) in children 4 years and older and adults who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light). 
ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.
ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis. 
ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older. Close
Woman with RA who has pain in her knee

What is
moderate to severe
rheumatoid arthritis?

Woman with RA who has pain in her knee

What is moderate to
severe rheumatoid arthritis?

About 1.3 million people in the United States have rheumatoid arthritis (RA). Moderate to severe RA is a lifelong condition that causes your joints to hurt and swell. Take a few minutes to learn more about moderate to severe RA in the information that follows.

  • Overview
  • Symptoms
  • Meet Erin
  • Patient Stories
  • What’s going on inside your body?

    Illustration of human joint Illustration of human joint

    Your immune system is designed to help protect your body from many harmful things. But if your immune system doesn’t work right, it can make you sick. When you have RA, cells from your immune system move into your joints. These cells make several proteins that can cause swelling and pain. One of these proteins is called tumor necrosis factor, or TNF. Too much TNF may lead to inflammation. Inflammation is what causes the pain, swelling, and damage of your joints over time.

    See what ENBREL does in response.
  • What are common signs and symptoms of RA?

    Doctor examines patient's hands Doctor examines patient's hands

    Most people with rheumatoid arthritis feel pain and stiffness in the morning. But there are other signs as well. Some people have joints that feel warm and/or feel swollen. Others notice that it gets harder to move around and do daily activities. In general, many people with RA also feel tired.

  • Could you have joint damage?

    Illustration of healthy joint versus damaged joint Illustration of healthy joint versus damaged joint

    If you feel joint pain, it may mean your joints are being damaged. However, joint damage can also continue to occur even when your pain is controlled with pain medication. Without an appropriate treatment for RA, damage can get worse more quickly. Notice how a healthy joint compares to a damaged joint.

    Learn how biologic treatments help stop further joint damage.
  • Who gets RA?

    Anyone can get rheumatoid arthritis, but more women do than men. In fact, women are 2-3 times more likely to have moderate to severe rheumatoid arthritis than men. RA usually begins between the ages of 45-64.

  • Is your RA getting worse?

    X-ray of patient's hands X-ray of patient's hands

    Rheumatoid arthritis can get worse quickly. If your joints hurt, it could mean your joints are also being damaged. However, joint damage can continue to occur even when pain is controlled. This damage cannot be undone. That’s why it’s important to talk to your doctor and find the best way to manage your condition.

    Download an ENBREL Appointment Guide.

5 common signs and symptoms of moderate to severe RA

Diagnosing rheumatoid arthritis can be tricky because each person with RA is affected differently. It does, however, have some common signs and symptoms:

morning

Joint stiffness—particularly in the morning (that lasts more than 30 minutes)

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Joint pain

hand-3

Joint swelling (often seen in the hands)

weakness

Weakness

tiredness-icon

Tiredness


Your doctor will look for these signs and symptoms to help diagnose you. He or she might also do blood tests and X-rays to look for other signs of RA. If you feel joint pain, it may be a sign of ongoing joint damage. Joint damage from RA is permanent and can’t be undone. When RA first starts, symptoms often affect the smaller joints, like the joints in your hands and feet. As time goes on, symptoms often move to your other joints—knees, ankles, spine, and jaw. Also, pain tends to affect the same joints on both sides of the body.

Track your symptoms.

Meet Erin*

See our latest commercial, and meet Erin: living with moderate to severe RA and being her true self.

*Actor Portrayal

Big Little Joys: Brandy's Story

Living Well With Rheumatoid Arthritis

Brandy enjoyed an active lifestyle until her rheumatoid arthritis (RA) worsened as an adult. That’s when Brandy’s doctor prescribed ENBREL, which she’s taken for 20 years. Watch how ENBREL helped Brandy as a special education teacher, grandmother, and advocate for the RA community.

Brandy enjoyed an active lifestyle until her rheumatoid arthritis (RA) worsened as an adult. That’s when Brandy’s doctor prescribed ENBREL, which she’s taken for 20 years. Watch how ENBREL helped Brandy as a special education teacher, grandmother, and advocate for the RA community.

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Doctor Discussion Guide

Use this simple guide to help your doctor understand how your moderate to severe RA is impacting your life, and ask whether ENBREL is right for you.

Download the Doctor Discussion Guide  »
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Joint Damage Simulator

Joint pain can be a sign of permanent joint damage. Use the Joint Damage Simulator to see how joint damage can get worse over time.

View the Joint Damage Simulator  »
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STATWISE Symptom Tracking Tool

STATWISE™ is a mobile-based symptom tracking tool designed for people living with moderate to severe rheumatoid arthritis.

Discover STATWISE™  »
+ See More

Important Safety Information

What is the most important information I should know about ENBREL?

ENBREL is a medicine that affects your immune

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections
have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have

 
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Prescription Enbrel® (etanercept) is taken (given) by injection.

Important Safety Information

What is the most important information I should know about ENBREL?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your healthcare provider should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.

There have been some cases of unusual cancers, some resulting in death, reported in children and teenage patients who started using tumor necrosis factor (TNF) blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA may be more likely to get lymphoma.

Before starting ENBREL, tell your healthcare provider if you:

  • Have any existing medical conditions
  • Are taking any medicines, including herbals
  • Think you have, are being treated for, have signs of, or are prone to infection. You should not start taking ENBREL if you have any kind of infection, unless your healthcare provider says it is okay
  • Have any open cuts or sores
  • Have diabetes, HIV, or a weak immune system
  • Have TB or have been in close contact with someone who has had TB
  • Were born in, lived in, or traveled to countries where there is more risk for getting TB. Ask your healthcare provider if you are not sure
  • Live, have lived in, or traveled to certain parts of the country (such as, the Ohio and Mississippi River valleys, or the Southwest) where there is a greater risk for certain kinds of fungal infections, such as histoplasmosis. These infections may develop or become more severe if you take ENBREL. If you don’t know if these infections are common in the areas you’ve been to, ask your healthcare provider
  • Have or have had hepatitis B
  • Have or have had heart failure
  • Develop symptoms such as persistent fever, bruising, bleeding, or paleness while taking ENBREL
  • Use the medicine Kineret (anakinra), Orencia (abatacept), or Cytoxan (cyclophosphamide)
  • Are taking anti-diabetic medicines
  • Have, have had, or develop a serious nervous disorder, seizures, any numbness or tingling, or a disease that affects your nervous system such as multiple sclerosis or Guillain-Barré syndrome
  • Are scheduled to have surgery
  • Have recently received or are scheduled for any vaccines. All vaccines should be brought up-to-date before starting ENBREL. Patients taking ENBREL should not receive live vaccines.
  • Are allergic to rubber or latex
  • Are pregnant, planning to become pregnant, or breastfeeding
  • Have been around someone with chicken pox

What are the possible side effects of ENBREL?

ENBREL can cause serious side effects including: New infections or worsening of infections you already have; hepatitis B can become active if you already have had it; nervous system problems, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes; blood problems (some fatal); new or worsening heart failure; new or worsening psoriasis; allergic reactions; autoimmune reactions, including a lupus-like syndrome and autoimmune hepatitis.

Common side effects include: Injection site reactions and upper respiratory infections (sinus infections).

In general, side effects in children were similar in frequency and type as those seen in adult patients. The types of infections reported were generally mild and similar to those usually seen in children.

These are not all the side effects with ENBREL. Tell your healthcare provider about any side effect that bothers you or does not go away.

If you have any questions about this information, be sure to discuss them with your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Prescribing Information and Medication Guide.

Indications

Moderate to Severe Rheumatoid Arthritis (RA)

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.

Psoriatic Arthritis

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.

Moderate to Severe Plaque Psoriasis

ENBREL is indicated for chronic moderate to severe plaque psoriasis (PsO) in children 4 years and older and adults who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light).

Ankylosing Spondylitis (AS)

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)

ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older.

References: 1. Parsabiv® (etelcalcetide) prescribing information, Amgen. 2. Data on file, Amgen; [Summary of Clinical Efficacy; 2015]. 3. Alexander ST, et al. Mol Pharmacol. 2015;88:853-865. 4. Data on file, Amgen; [Report R20130052, 2014]. 5. Chen P, et al. CPT Pharmacometrics Syst Pharmacol. 2016;5:484-494. 6. Sensipar® (cinacalcet) prescribing information, Amgen. 7. Ma JN, et al. J Pharmacol Exp Ther. 2011;337:275-284.
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