Indications

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone. Read more

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What is psoriatic arthritis (PsA)?

When you have PsA, your immune system creates too much of a protein called tumor necrosis factor (TNF). That extra TNF leads to inflammation in your joints. Symptoms may include joint pain, swelling, and stiffness. But the inflammation can also affect your skin—causing patches of thick, red areas with silvery type scales called plaques. With PsA, usually skin symptoms start first, then the joint pain—which mostly affects the hands, knees, ankles, or feet.

What is psoriatic arthritis (PsA)?

When you have PsA, your immune system creates too much of a protein called tumor necrosis factor (TNF). That extra TNF leads to inflammation in your joints. Symptoms may include joint pain, swelling, and stiffness. But the inflammation can also affect your skin—causing patches of thick, red areas with silvery type scales called plaques. With PsA, usually skin symptoms start first, then the joint pain—which mostly affects the hands, knees, ankles, or feet.

WHY ENBREL?

How can ENBREL help you with adult psoriatic arthritis?

How can ENBREL help you with adult psoriatic arthritis?

Joint pain icon

ENBREL helps

significantly relieve joint pain

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and helps

stop permanent joint damage

caused by PsA. Plus it can help skin get clearer.

ENBREL is a type of medicine called a biologic (a treatment made from living cells). It’s designed to attach to TNF proteins to help block their activity and help relieve the joint pain, stiffness, and skin lesions of adult PsA. Treating adult PsA with ENBREL can help you get back to many of the moments that make you who you are.

Try out our Joint Damage Simulator to see how joint damage can progress.

Try out our Joint Damage Simulator to see how joint damage can progress

ENBREL is a type of medicine called a biologic (a treatment made from living cells). It’s designed to attach to TNF proteins to help block their activity and help relieve the joint pain, stiffness, and skin lesions of adult PsA. Treating adult PsA with ENBREL can help you get back to many of the moments that make you who you are.

Try out our Joint Damage Simulator to see how joint damage can progress.

How long does it take for ENBREL to work for adult psoriatic arthritis?

ENBREL works differently with each person. Your results may vary.

In a medical study:

Timeline of how long it takes ENBREL® to work for psoriatic arthritis
Timeline of how long it takes ENBREL® to work for psoriatic arthritis

Keep taking ENBREL as prescribed by your doctor to see how ENBREL might work for you. Keep in mind your results may vary. You may need to give ENBREL time to work.

Be sure to work with your doctor throughout your treatment with ENBREL.

Rheumatoid Arthritis & Psoriatic Arthritis

Joint Damage Simulator

Psoriatic arthritis can lead to irreversible joint damage.

What does permanent joint damage look like? Use this Joint Damage Simulator to see how joint damage can get worse over time.

Whether you have moderate to severe rheumatoid arthritis (RA) or psoriatic arthritis (PsA), joint pain, stiffness, and swelling are common reminders of your condition. They can also be a sign of something else: permanent joint damage that cannot be undone.

Use the Joint Damage Simulator to see how permanent joint damage can progress if not treated with the right kinds of medication.

Watch how joint damage may progress over time.*

Rheumatoid Arthritis & Psoriatic ArthritisJoint Damage Simulator

POSSIBLE SIDE EFFECTS

Common side effects include: Injection site reactions and upper respiratory infections (sinus infections).

Injection site reactions from ENBREL®

Injection site reactions can include redness, itching, pain, swelling, bleeding, or bruising. These symptoms usually go away within 3 to 5 days. If you have pain, redness, or swelling around the injection site that does not go away or gets worse, call your healthcare provider.

Side effects of ENBREL®

ENBREL can cause serious side effects including: New infections or worsening of infections you already have, including tuberculosis; lymphoma and other cancers; hepatitis B can become active if you already have had it; nervous system problems, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes; blood problems (some fatal); new or worsening heart failure; new or worsening psoriasis; allergic reactions; autoimmune reactions, including a lupus-like syndrome and autoimmune hepatitis. See Important Safety Information below.

For children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA may be more likely to get lymphoma.

Everybody’s experience with ENBREL is different. It’s important to talk to your doctor about whether ENBREL is right for you and learn about its possible side effects.

Overall, out of the 3,743 people treated with ENBREL across clinical trials for different conditions*, about 4% stopped using ENBREL due to side effects.

*Rheumatoid arthritis, adult psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis.

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*Rheumatoid arthritis, adult psoriatic arthritis, ankylosing spondylitis, and plaque psoriasis.

TALKING TO
YOUR DOCTOR

3 topics to bring up with your healthcare provider

Many doctors find the information below valuable when deciding on the right PsA medication and treatment plan for their patients. Make the most of your next doctor’s appointment by preparing to discuss the following:

#1 How is psoriatic arthritis making you feel overall?

Has your joint pain or morning stiffness been better or worse over the last couple of weeks?

#2 Any new or worsening symptoms?

They could be a sign that your PsA is progressing—and if that’s the case, your doctor may want to adjust your treatment plan.

#3 How do your symptoms affect your daily activities?

Has getting out of bed, dressing yourself or walking up stairs become more difficult?

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Prescription Enbrel® (etanercept) is taken (given) by injection.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ENBREL?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your healthcare provider should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.

There have been some cases of unusual cancers, some resulting in death, reported in children and teenagers who started using tumor necrosis factor (TNF) blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA may be more likely to get lymphoma.

Before starting ENBREL, tell your healthcare provider if you:

  • Have any existing medical conditions
  • Are taking any medicines, including herbals
  • Think you have, are being treated for, have signs of, or are prone to infection. You should not start taking ENBREL if you have any kind of infection, unless your healthcare provider says it is okay
  • Have any open cuts or sores
  • Have diabetes, HIV, or a weak immune system
  • Have TB or have been in close contact with someone who has had TB
  • Were born in, lived in, or traveled to countries where there is more risk for getting TB. Ask your healthcare provider if you are not sure
  • Live, have lived in, or traveled to certain parts of the country (such as, the Ohio and Mississippi River valleys, or the Southwest) where there is a greater risk for certain kinds of fungal infections, such as histoplasmosis. These infections may develop or become more severe if you take ENBREL. If you don’t know if these infections are common in the areas you’ve been to, ask your healthcare provider
  • Have or have had hepatitis B
  • Have or have had heart failure
  • Develop symptoms such as persistent fever, bruising, bleeding, or paleness while taking ENBREL
  • Use the medicine Kineret (anakinra), Orencia (abatacept), or Cytoxan (cyclophosphamide)
  • Are taking anti-diabetic medicines
  • Have, have had, or develop a serious nervous disorder, seizures, any numbness or tingling, or a disease that affects your nervous system such as multiple sclerosis or Guillain-Barré syndrome
  • Are scheduled to have surgery
  • Have recently received or are scheduled for any vaccines. All vaccines should be brought up-to-date before starting ENBREL. Patients taking ENBREL should not receive live vaccines
  • Are pregnant, planning to become pregnant, or breastfeeding
  • Have been around someone with chicken pox

What are the possible side effects of ENBREL?

ENBREL can cause serious side effects including: New infections or worsening of infections you already have; hepatitis B can become active if you already have had it; nervous system problems, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes; blood problems (some fatal); new or worsening heart failure; new or worsening psoriasis; allergic reactions; autoimmune reactions, including a lupus-like syndrome and autoimmune hepatitis.

Common side effects include: Injection site reactions and upper respiratory infections (sinus infections).

In general, side effects in children were similar in frequency and type as those seen in adult patients. The types of infections reported were generally mild and similar to those usually seen in children.

These are not all the side effects with ENBREL. Tell your healthcare provider about any side effect that bothers you or does not go away.

If you have any questions about this information, be sure to discuss them with your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Prescribing Information and Medication Guide.

INDICATIONS

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.

ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (pJIA) in children 2 years of age or older.

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in adult patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.

ENBREL is indicated for active juvenile psoriatic arthritis (JPsA) in children 2 years of age or older.

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

ENBREL is indicated for chronic moderate to severe plaque psoriasis (PsO) in children 4 years of age or older and adults who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light).

Prescription Enbrel® (etanercept) is taken (given) by injection.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ENBREL?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections.