Explore a condition below
Page Highlights:
  • Get answers about insurance, injecting, travel, side effects, and more
  • Schedule a call to talk to a support specialist

Common questions about ENBREL

We know questions come up. Pick a topic below to find answers to frequently asked questions about ENBREL. If your question isn’t answered below, call 1-888-4ENBREL (1-888-436-2735) or schedule a call for a better time and we'll be happy to help.

Insurance and Medicare
Will my insurance cover ENBREL?
A. 

Many insurance plans cover ENBREL. To find out if yours does, call one of our insurance specialists at 1-888-4ENBREL (1-888-436-2735). Please have your insurance card and information ready when you call. You can also verify your insurance here.

What if my insurance does not cover ENBREL?
A. 

Our insurance specialists may be able to help. There are several steps we can take to help you get payment from your insurance company. For example, we have materials that can help you and your doctor in asking for coverage, such as sample advocacy letters, appeal letters, and letters of medical necessity. Call us at 1-888-4ENBREL (1-888-436-2735), Monday through Friday, from 8 AM to 8 PM ET.

Read more about paying for ENBREL

Does Medicare cover ENBREL?
A. 

Medicare plans vary in what medicines they cover, and how long they are covered. If you have Medicare, you can sign up for a plan that can help cover the cost of ENBREL. Our Medicare Solutions team can help you decide which plan may be right for you. Medicare Solutions specialists are available Monday through Friday, from 8 AM to 8 PM ET. Just call 1-888-4ENBREL (1-888-436-2735), and choose option #6. Learn more about Medicare

Does Medicaid cover ENBREL?
A. 

Each Medicaid agency is different. Our Medicare Solutions team can call your agency and ask about your Medicaid coverage. Medicare Solutions specialists are available Monday through Friday, from 8 AM to 8 PM ET. Just call 1-888-4ENBREL (1-888-436-2735), and choose option #6.

How do I get insurance prior authorization for ENBREL?
A. 

Our insurance specialists can help you and your doctor get the documentation you need to get a prescription for ENBREL. Call us at 1-888-4ENBREL (1-888-436-2735), Monday through Friday, from 8 AM to 8 PM ET. Please have your insurance information ready.

Dosing Guidelines
How much ENBREL do I need to take, and how often?
A. 

Dosing varies based on indication.
For moderate to severe rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis
Your doctor will recommend the best dose and dosing schedule for you. But, in general, the recommended dose of ENBREL is 50 mg, once a week.

For moderate to severe plaque psoriasis
Your doctor will recommend the best dose and dosing schedule for you. But the dosing schedule is generally:

  • First 3 months: ENBREL 50 mg, twice a week (3 or 4 days apart)
  • After 3 months: ENBREL 50 mg, once a week for maintenance

Your doctor may also choose to start you with 25 mg or 50 mg of ENBREL, once per week. Ask your doctor what dose is right for you.

For moderate to severe polyarticular juvenile idiopathic arthritis
Your doctor will recommend the best dose and dosing schedule for your child. But, for most children, dosing is based on weight:

  • If your child weighs 138 lbs or more: ENBREL 50 mg, once a week
  • If your child weighs less than 138 lbs: ENBREL 0.8 mg/kg, once a week
I missed a dose. What should I do?
A. 

If you forget to take ENBREL when you are supposed to, call your doctor to find out when you should take your next dose. It’s important to take ENBREL as scheduled, in order to maintain your results. If you need help remembering to take ENBREL, you can sign up for medicine reminders (via phone or email) by calling 1-888-4ENBREL (1-888-436-2735).

Can I get a refresher on how to inject ENBREL?
A. 

You can watch demonstrations and get information about injecting online. Watch demos.

Injecting ENBREL
How do I inject ENBREL?
A. 

Your doctor or nurse will train you on how to inject ENBREL. After that, you can watch these injection demos and read the Instructions for Use.

Where on the body do I inject ENBREL?
A. 

You can inject ENBREL on the front of the middle thighs, on the outer area of your upper arms, or on your stomach (except for the 2-inch area around your belly button). You should switch between injection sites to help avoid an infection.

See how to take ENBREL

Skin reactions around the injection area, such as redness, pain, swelling, itching, or bruising have happened. On average, these symptoms go away within 3 to 5 days. If you have any of these reactions and they don't go away or get worse, call your doctor.

Can I let ENBREL warm up before injecting?
A. 

Injecting cold ENBREL can be uncomfortable. To help make it more comfortable, take ENBREL out of the fridge and wait for it to reach room temperature (which should take about 15 to 30 minutes). Do not warm it in a microwave or in hot water, and do not remove the needle cover while you wait. Keep these guidelines in mind:

  • In general, store ENBREL in the refrigerator at 36°F to 46°F (2°C to 8°C)
  • You may store the ENBREL syringe, autoinjector, or the dose tray for the multi‐use vial at room temperature between 68°F and 77°F (20°C and 25°C) for up to 14 days
  • Once ENBREL has reached room temperature, do not put it back in the refrigerator
  • Throw away ENBREL that has been stored at room temperature after 14 days

Learn about room temperature storage

Should I be worried if my skin around the injection site gets red and itchy?
A. 

Sometimes this can happen. Some common injection site reactions include redness, pain, swelling, itching, or bruising. However, these symptoms tend to go away within 3 to 5 days. If they don’t go away or get worse, call your doctor. Learn about possible side effects

After mixing the liquid and powder, the solution in the vial looks cloudy. Is that ok?
A. 

If you’re using the multi-use vial, make sure that the mixed, dissolved solution is clear and colorless before injecting. (A small amount of foam or bubbles is okay.) If you notice any of the following, do not inject ENBREL and call 1-888-4ENBREL (1-888-436-2735):

  • The color doesn’t look right
  • Medicine has lumps, flakes, or colored particles
  • The powder in the vial is not fully dissolved
  • There are still particles after 10 minutes

What should I do if the needle is bent or the autoinjector is damaged?
A. 

If a needle or an autoinjector is damaged in any way, don't try to use it or fix it. Also, don’t throw it away. Call 1-888-4ENBREL (1-888-436-2735) and we will help you.

Disposal after injecting
What should I do with my needles, syringes, or autoinjectors after injecting?
A. 

Right after injecting, discard your needle, syringe, or autoinjector in a puncture-resistant sharps disposal container (do not recap or reuse). You can buy one at your local pharmacy, or call ENBREL Support at 1-888-4ENBREL (1-888-436-2735) to get one for free.

What should I do with my needle disposal container once it's full?
A. 

You can sign up for the ENBREL Sharps Mail-Back Program, which gives you a safe, convenient way to dispose of your injection materials for free. Call 1-888-4ENBREL (1-888-436-2735) to join.

How does the program work?
  • About 7-10 days after joining, you’ll get a 1 gallon sharps disposal container, along with a postage paid shipping container
  • When the sharps disposal container is almost full, you can re-order a new one by calling 1-888-4ENBREL (1-888-436-2735). (Never empty your container to reuse it)
  • You will also get a reminder e-mail that lets you re-order online
  • Once the new sharps disposal container arrives, put the filled container in the postage-paid shipping container and put it in the mailbox for return
  • Sharps Compliance Inc. will then safely process and recycle the used injection materials

If you choose not to use the Sharps Mail-Back Program, throw away the container using the directions from your doctor. State and local laws for throwing away needles vary from town to town. Do not recycle the sharps disposal container or put it in the trash (unless your local laws permit this).

Side effects
What are the most common side effects of ENBREL?
A. 

The most common side effects of ENBREL are infections (like the common cold, sinusitis, and the flu) and injection site reactions. Injection site reactions are mild to moderate (redness, itching, pain, swelling, bleeding, and bruising) and usually go away within 3 to 5 days. If you have injection site reactions that don’t go away or get worse, call your doctor.

Learn more about possible side effects

What should I do if I get a fever or infection while taking ENBREL?
A. 

If you get an infection, especially one with a fever, you need to contact your doctor right away.

Learn more about possible side effects

Vaccines and Flu Shots
Can I get vaccines and flu shots while taking ENBREL?
A. 

Your vaccinations should be brought up to date before starting ENBREL. While you are taking ENBREL, you may be able to get some vaccines, including certain types of flu shots. You should not receive any live vaccines while taking ENBREL. Talk to your doctor before receiving vaccines, including flu shots, if you are taking ENBREL.

Storage
How should I store ENBREL?
A. 

ENBREL should be kept cool—between 36°F and 46°F (2°C and 8°C; the standard temperature range of most refrigerators). However, ENBREL can also be stored at room temperature between 68°F and 77°F (20°C and 25°C) for up to 14 days. Once ENBREL has reached room temperature, do not put it back in the refrigerator. Throw away ENBREL that has been stored at room temperature after 14 days.

Learn more about storage and travel

Can I still use ENBREL if I take it out of the fridge but don't use it right away?
A. 

ENBREL can stay at room temperature between 68°F and 77°F (20°C and 25°C) for up to 14 days. However, once it reaches room temperature, you cannot put it back in the fridge. Throw away ENBREL that has been stored at room temperature for more than 14 days. If you use the Multi-use vial, mixed ENBREL powder should be used right away or kept in the fridge at 36°F to 46°F (2°C to 8°C) for up to 14 days. Learn more about storage and travel

Travel
How should I travel with ENBREL?
A. 

One option is to keep ENBREL cool while you travel. If you choose to keep it cool, keep it in its original box, wrap it in bubble wrap, and place it in a cooler. You can order a free travel cooler by calling 1-888-4ENBREL (1-888-436-2735). Add ice as needed to keep the temperature at 36°F to 46°F (2°C to 8°C). Always keep ENBREL and all medicines away from children.

Another option is to keep ENBREL at room temperature between 68°F and 77°F (20°C and 25°C) and use it within 14 days. But remember that once ENBREL reaches room temperature, you cannot put it back in the fridge. Throw away ENBREL that has been stored at room temperature after 14 days.

Learn more about storage and travel

Can I fly with my ENBREL needles, syringes, or autoinjectors?
A. 

Check with your airline before you travel. They can tell you whether you can carry needles, syringes, or autoinjectors onto the plane. It is also a good idea to carry a copy of your prescription or a doctor’s note to show airport security. Notify the screener if you are carrying a sharps disposal container in your carry-on baggage. Learn more about storage and travel

Pregnancy and nursing
Can I take ENBREL if I am pregnant or trying to get pregnant?
A. 

Before starting ENBREL, you should tell your doctor if you are pregnant or planning to get pregnant. ENBREL should be used during pregnancy only if clearly needed. If you become pregnant while taking ENBREL, you are encouraged to enroll in Amgen’s Pregnancy Surveillance Program. You can enroll by calling 1-800-77-AMGEN (1-800-772-6436).

Can I take ENBREL if I'm nursing?
A. 

Nursing mothers should know that ENBREL can pass into breast milk and may harm nursing infants. Work with your doctor to decide whether you will take ENBREL or breastfeed. You should not do both. If you choose to breastfeed while taking ENBREL, you are encouraged to enroll in Amgen’s Lactation Surveillance Program. You can enroll by calling 1-800-77-AMGEN (1-800-772-6436).

Surgery
Do I need to stop taking ENBREL if I’m having surgery?
A. 

Sometimes surgery increases your chances of getting an infection. Because ENBREL can also increase your risk of getting an infection, your doctor may want you to stop taking ENBREL for a while before and after your operation.

Latex allergies
Is there latex in the autoinjector, prefilled syringe, or multi-use vial?
A. 

If you are sensitive to latex, do not handle the autoinjector or the prefilled syringe. The syringe caps on these devices are made of dry natural rubber (which comes from latex). Talk to your doctor about the best injection method for you.

ENBREL and methotrexate
Can ENBREL be taken with methotrexate?
A. 

In moderate to severe rheumatoid arthritis (RA) and psoriatic arthritis, ENBREL can be taken with or without methotrexate to help reduce joint pain and help stop additional joint damage.

In medical studies of patients with moderate to severe RA, ENBREL was proven to help reduce joint pain and stop further joint damage better than methotrexate alone. And, people taking ENBREL for 6 months had far less joint pain and damage than people who only took methotrexate. Your results may vary. Ask your doctor if ENBREL and methotrexate could work for you.

Please see the full Prescribing Information, Important Safety Information, and Medication Guide for more details about ENBREL.

Prescription Enbrel® (etanercept) is taken by injection.

IMPORTANT SAFETY INFORMATION
What is the most important information I should know about ENBREL?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your doctor should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.

There have been some cases of unusual cancers reported in children and teenage patients who started using tumor necrosis factor (TNF) blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA or psoriasis may be more likely to get lymphoma.

Before starting ENBREL, tell your doctor if you:
  • Have any existing medical conditions
  • Are taking any medicines, including herbals
  • Think you have, are being treated for, have signs of, or are prone to infection. You should not start taking ENBREL if you have any kind of infection, unless your doctor says it is okay
  • Have any open cuts or sores
  • Have diabetes, HIV, or a weak immune system
  • Have TB or have been in close contact with someone who has had TB
  • Were born in, lived in, or traveled to countries where there is more risk for getting TB. Ask your doctor if you are not sure
  • Live, have lived in, or traveled to certain parts of the country (such as, the Ohio and Mississippi River valleys, or the Southwest) where there is a greater risk for certain kinds of fungal infections, such as histoplasmosis. These infections may develop or become more severe if you take ENBREL. If you don’t know if these infections are common in the areas you’ve been to, ask your doctor
  • Have or have had hepatitis B
  • Have or have had heart failure
  • Develop symptoms such as persistent fever, bruising, bleeding, or paleness while taking ENBREL
  • Use the medicine Kineret® (anakinra), Orencia® (abatacept), or Cytoxan® (cyclophosphamide)
  • Are taking anti-diabetic medicines
  • Have, have had, or develop a serious nervous disorder, seizures, any numbness or tingling, or a disease that affects your nervous system such as multiple sclerosis or Guillain-Barré syndrome
  • Are scheduled to have surgery
  • Have recently received or are scheduled for any vaccines. All vaccines should be brought up-to-date before starting ENBREL. Patients taking ENBREL should not receive live vaccines.
  • Are allergic to rubber or latex
  • Are pregnant, planning to become pregnant, or breastfeeding
  • Have been around someone with chicken pox
What are the possible side effects of ENBREL?

ENBREL can cause serious side effects including: New infections or worsening of infections you already have; hepatitis B can become active if you already have had it; nervous system problems, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes; blood problems (some fatal); new or worsening heart failure; new or worsening psoriasis; allergic reactions; autoimmune reactions, including a lupus-like syndrome and autoimmune hepatitis.

Common side effects include: Injection site reactions, upper respiratory infections (sinus infections), and headache.

In a medical study of patients with JIA, side effects were generally similar in frequency and type as those seen in adult patients. The kinds of infections reported were generally mild and similar to those usually seen in children.

These are not all the side effects with ENBREL. Tell your doctor about any side effect that bothers you or does not go away.

If you have any questions about this information, be sure to discuss them with your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Prescribing Information and Medication Guide.

INDICATIONS
Moderate to Severe Rheumatoid Arthritis (RA)

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.

Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)

ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older.

Psoriatic Arthritis

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.

Ankylosing Spondylitis (AS)

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

Moderate to Severe Plaque Psoriasis

ENBREL is indicated for the treatment of adult patients (18 years or older) with chronic moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

IMPORTANT SAFETY INFORMATION
What is the most important information I should know about ENBREL?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your doctor should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.

There have been some cases of unusual cancers reported in children and teenage patients who started using tumor necrosis factor (TNF) blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA or psoriasis may be more likely to get lymphoma.

Before starting ENBREL, tell your doctor if you:
What are the possible side effects of ENBREL?

ENBREL can cause serious side effects including: New infections or worsening of infections you already have; hepatitis B can become active if you already have had it; nervous system problems, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes; blood problems (some fatal); new or worsening heart failure; new or worsening psoriasis; allergic reactions; autoimmune reactions, including a lupus-like syndrome and autoimmune hepatitis.

Common side effects include: Injection site reactions, upper respiratory infections (sinus infections), and headache.

In a medical study of patients with JIA, side effects were generally similar in frequency and type as those seen in adult patients. The kinds of infections reported were generally mild and similar to those usually seen in children.

These are not all the side effects with ENBREL. Tell your doctor about any side effect that bothers you or does not go away.

If you have any questions about this information, be sure to discuss them with your doctor. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Prescribing Information and Medication Guide.

INDICATIONS
Moderate to Severe Rheumatoid Arthritis (RA)

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.

Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)

ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older.

Psoriatic Arthritis

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.

Ankylosing Spondylitis (AS)

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

Moderate to Severe Plaque Psoriasis

ENBREL is indicated for the treatment of adult patients (18 years or older) with chronic moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

  • Close
IMPORTANT SAFETY INFORMATION: What is the most important information I should know about Enbrel® (etanercept)?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis(TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your doctor should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.

There have been some cases of unusual cancers reported in children and teenage patients who started using tumor necrosis factor (TNF) blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA or psoriasis may be more likely to get lymphoma.

Before starting ENBREL, tell your doctor if you:

What are the possible side effects of ENBREL?

ENBREL can cause serious side effects including: New infections or worsening of infections
you already have; hepatitis B can become active if you already have had it; nervous system
problems
, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes;
blood problems (some fatal); new or worsening heart failure; new or worsening psoriasis;
allergic reactions; autoimmune reactions, including a lupus-like syndrome and autoimmune
hepatitis.

Common side effects include: Injection site reactions, upper respiratory infections (sinus
infections), and headache.

In a medical study of patients with JIA, side effects were generally similar in frequency and type as those seen in adult patients. The kinds of infections reported were generally mild and similar to those usually seen in children.

These are not all the side effects with ENBREL. Tell your doctor about any side effect that
bothers you or does not go away.

If you have any questions about this information, be sure to discuss them with your doctor.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit
www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Prescribing Information and Medication Guide.

INDICATIONS
Moderate to Severe Rheumatoid Arthritis (RA)

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting
worse, and improving physical function in patients with moderately to severely active rheumatoid
arthritis. ENBREL can be taken with methotrexate or used alone.

Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)

ENBREL is indicated for reducing signs and symptoms of moderately to severely active
polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older.

Psoriatic Arthritis

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting
worse, and improving physical function in patients with psoriatic arthritis. ENBREL can be
used with or without methotrexate.

Ankylosing Spondylitis(AS)

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing
spondylitis.

Moderate to Severe Plaque Psoriasis

ENBREL is indicated for the treatment of adult patients (18 years or older) with chronic
moderate to severe plaque psoriasis who are candidates for systemic therapy or
phototherapy.



At Enbrel.com, you can learn about Enbrel® (etanercept), a self-injected biologic medicine
used to treat inflammatory diseases with long-term effects. You can find information about
moderate to severe rheumatoid arthritis(RA), moderate to severe plaque psoriasis, psoriatic
arthritis, moderately to severely active polyarticular juvenile idiopathic arthritis(JIA), and
ankylosing spondylitis(AS). You can learn about symptoms, treatment, how Enbrel®
(etanercept) works for each condition, results for each condition, results for each condition, and safety information.

Enbrel.com supports you and your loved ones from diagnosis to treatment. You can find
resources like injection demonstrations, patient testimonial videos, questions to ask your
doctor, and even help with finding a rheumatologist or dermatologist near you.

Enbrel.com also provices ongoing assistance with ENBREL SupportTM, a patient support
program to help with out-of-pocket costs and connect you with registered nurses and
ENBREL Nurse Partners. The resources available will help you get started. Resources
include the ENBREL Starter Kit, injection and medicine refill reminders, free needle disposal
containers, travel packs, and ongoing education.

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IMPORTANT SAFETY INFORMATION:
What is the most important information I should know about Enbrel® (etanercept)?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your doctor should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.