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moderate to severe
Rheumatoid Arthritis
moderate to severe
Plaque Psoriasis
Psoriatic Arthritis
Ankylosing Spondylitis
moderate to severe polyarticular
Juvenile Idiopathic Arthritis (JIA)

Phil Mickelson’s story

▶ Read the full video transcript

I think the first real signs of psoriatic arthritis were some pain and stiffness near my ankle, and that made it really hard to walk. Then I began to notice it in other areas as well… in my fingers, in my wrists. At first I thought it was from years of playing golf, and I just figured it would get better.

The tipping point for me happened not long after the U.S. Open. I was in a tremendous amount of pain. That’s when I called our family doctor.

Neither of us knew what the problem was, so he told me I needed to see a rheumatologist right away. So that’s what I did.

It didn’t take long before I was diagnosed with psoriatic arthritis.

Of course I was really concerned and overwhelmed. Physical functionality is obviously very important to me. But after talking to my rheumatologist and learning more about the condition, I felt more confident that there was something we could do about it. That was the good news—it was treatable.

My doctor and I talked about a few different options. Specifically, we talked about the idea of taking methotrexate. We also talked about TNF inhibitors.

My rheumatologist thought ENBREL would be a good option for managing my symptoms and helping to stop joint damage progression. Also, I do remember my rheumatologist telling me that the longer I waited to start treatment, the greater the potential for joint damage. And that’s a scary thing—especially when you can do something about it.

After a few weeks of taking ENBREL, I started noticing changes. I remember one day in particular… I was in a restaurant with a few friends, probably a month after I began treatment.

I was just sitting there and I turned to my friend, raised my left index finger, and bent it to touch my palm. That was the first time I’d been able to do that in months. It sounds like a silly thing, but it was progress.

I was definitely seeing good results, and as time went on, I had many more moments like that. Now, after being on ENBREL, my symptoms are well managed. I can do many of the things I want to do.

I am so happy I consulted my rheumatologist and began treatment.

See how ENBREL helps Phil Mickelson manage his symptoms

We are lucky in life when we can pursue our passion, as I've been able to do in my career. Every day I'm thankful that I can play golf and spend quality time with my wife and my three children. But my life as I knew it was suddenly turned upside down when I began experiencing joint stiffness and severe pain.

In the months leading up to the 2010 US Open, I developed pain near my ankle that made it difficult to walk, and my left index finger and right wrist felt as if they were sprained. At first, I thought these aches could be caused by years of practicing and playing golf and that they would eventually pass. Then, after two days of preparing for the US Open, I awoke and the pain in my joints was so intense I could hardly get out of bed.

"Once I saw my rheumatologist and received the information I needed, I felt confident that together we would find the right treatment to manage my condition."

With the support of my loved ones, I decided to act quickly and educate myself about my symptoms. I found a rheumatologist who was able to provide me with some answers as to why I was feeling so badly. In the week following the US Open, I was diagnosed with psoriatic arthritis.

Once I saw my rheumatologist and received the information I needed to understand my symptoms, learn my diagnosis, and make an informed decision for me about my treatment options, I felt confident that together we would find the right treatment to manage my condition. Since then, I have been diligent about taking my treatment and have followed my rheumatologist's recommendations to improve my overall health to help me stay "on course" both professionally and at home. I've continued to play golf and have been able to keep doing fun things with my family, like playing catch or going for a swim or a hike. I feel good!

Sincerely,

Phil Mickelson
Your results may vary.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ENBREL?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your healthcare provider should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.

There have been some cases of unusual cancers, some resulting in death, reported in children and teenage patients who started using tumor necrosis factor (TNF) blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA may be more likely to get lymphoma.

Before starting ENBREL, tell your healthcare provider if you:

Have any existing medical conditions
Are taking any medicines, including herbals
Think you have, are being treated for, have signs of, or are prone to infection. You should not start taking ENBREL if you have any kind of infection, unless your healthcare provider says it is okay
Have any open cuts or sores
Have diabetes, HIV, or a weak immune system
Have TB or have been in close contact with someone who has had TB
Were born in, lived in, or traveled to countries where there is more risk for getting TB. Ask your healthcare provider if you are not sure
Live, have lived in, or traveled to certain parts of the country (such as, the Ohio and Mississippi River valleys, or the Southwest) where there is a greater risk for certain kinds of fungal infections, such as histoplasmosis. These infections may develop or become more severe if you take ENBREL. If you don’t know if these infections are common in the areas you’ve been to, ask your healthcare provider
Have or have had hepatitis B
Have or have had heart failure
Develop symptoms such as persistent fever, bruising, bleeding, or paleness while taking ENBREL
Use the medicine Kineret (anakinra), Orencia (abatacept), or Cytoxan (cyclophosphamide)
Are taking anti-diabetic medicines
Have, have had, or develop a serious nervous disorder, seizures, any numbness or tingling, or a disease that affects your nervous system such as multiple sclerosis or Guillain-Barré syndrome
Are scheduled to have surgery
Have recently received or are scheduled for any vaccines. All vaccines should be brought up-to-date before starting ENBREL. Patients taking ENBREL should not receive live vaccines.
Are allergic to rubber or latex
Are pregnant, planning to become pregnant, or breastfeeding
Have been around someone with chicken pox

What are the possible side effects of ENBREL?

ENBREL can cause serious side effects including: New infections or worsening of infections you already have; hepatitis B can become active if you already have had it; nervous system problems, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes; blood problems (some fatal); new or worsening heart failure; new or worsening psoriasis; allergic reactions; autoimmune reactions, including a lupus-like syndrome and autoimmune hepatitis.

Common side effects include: Injection site reactions and upper respiratory infections (sinus infections).

In general, side effects in children were similar in frequency and type as those seen in adult patients. The types of infections reported were generally mild and similar to those usually seen in children.

These are not all the side effects with ENBREL. Tell your healthcare provider about any side effect that bothers you or does not go away.

If you have any questions about this information, be sure to discuss them with your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Prescribing Information and Medication Guide.

INDICATIONS

Moderate to Severe Rheumatoid Arthritis (RA)

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.

Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)

ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older.

Psoriatic Arthritis

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.

Ankylosing Spondylitis (AS)

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

Moderate to Severe Plaque Psoriasis

ENBREL is indicated for chronic moderate to severe plaque psoriasis (PsO) in children 4 years and older and adults who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light).

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ENBREL?

Before starting ENBREL, tell your healthcare provider if you:

Have any existing medical conditions
Are taking any medicines, including herbals
Think you have, are being treated for, have signs of, or are prone to infection. You should not start taking ENBREL if you have any kind of infection, unless your healthcare provider says it is okay
Have any open cuts or sores
Have diabetes, HIV, or a weak immune system
Have TB or have been in close contact with someone who has had TB
Were born in, lived in, or traveled to countries where there is more risk for getting TB. Ask your healthcare provider if you are not sure
Live, have lived in, or traveled to certain parts of the country (such as, the Ohio and Mississippi River valleys, or the Southwest) where there is a greater risk for certain kinds of fungal infections, such as histoplasmosis. These infections may develop or become more severe if you take ENBREL. If you don’t know if these infections are common in the areas you’ve been to, ask your healthcare provider
Have or have had hepatitis B
Have or have had heart failure
Develop symptoms such as persistent fever, bruising, bleeding, or paleness while taking ENBREL
Use the medicine Kineret (anakinra), Orencia (abatacept), or Cytoxan (cyclophosphamide)
Are taking anti-diabetic medicines
Have, have had, or develop a serious nervous disorder, seizures, any numbness or tingling, or a disease that affects your nervous system such as multiple sclerosis or Guillain-Barré syndrome
Are scheduled to have surgery
Have recently received or are scheduled for any vaccines. All vaccines should be brought up-to-date before starting ENBREL. Patients taking ENBREL should not receive live vaccines.
Are allergic to rubber or latex
Are pregnant, planning to become pregnant, or breastfeeding
Have been around someone with chicken pox

What are the possible side effects of ENBREL?

Common side effects include: Injection site reactions and upper respiratory infections (sinus infections).

These are not all the side effects with ENBREL. Tell your healthcare provider about any side effect that bothers you or does not go away.

Please see Prescribing Information and Medication Guide.

INDICATIONS

Moderate to Severe Rheumatoid Arthritis (RA)

Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)

ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older.

Psoriatic Arthritis

Ankylosing Spondylitis (AS)

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

Moderate to Severe Plaque Psoriasis

See More
See More

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ENBREL?

Before starting ENBREL, tell your healthcare provider if you:

Have any existing medical conditions
Are taking any medicines, including herbals
Think you have, are being treated for, have signs of, or are prone to infection. You should not start taking ENBREL if you have any kind of infection, unless your healthcare provider says it is okay
Have any open cuts or sores
Have diabetes, HIV, or a weak immune system
Have TB or have been in close contact with someone who has had TB
Were born in, lived in, or traveled to countries where there is more risk for getting TB. Ask your healthcare provider if you are not sure
Live, have lived in, or traveled to certain parts of the country (such as, the Ohio and Mississippi River valleys, or the Southwest) where there is a greater risk for certain kinds of fungal infections, such as histoplasmosis. These infections may develop or become more severe if you take ENBREL. If you don’t know if these infections are common in the areas you’ve been to, ask your healthcare provider
Have or have had hepatitis B
Have or have had heart failure
Develop symptoms such as persistent fever, bruising, bleeding, or paleness while taking ENBREL
Use the medicine Kineret (anakinra), Orencia (abatacept), or Cytoxan (cyclophosphamide)
Are taking anti-diabetic medicines
Have, have had, or develop a serious nervous disorder, seizures, any numbness or tingling, or a disease that affects your nervous system such as multiple sclerosis or Guillain-Barré syndrome
Are scheduled to have surgery
Have recently received or are scheduled for any vaccines. All vaccines should be brought up-to-date before starting ENBREL. Patients taking ENBREL should not receive live vaccines.
Are allergic to rubber or latex
Are pregnant, planning to become pregnant, or breastfeeding
Have been around someone with chicken pox

What are the possible side effects of ENBREL?

Common side effects include: Injection site reactions and upper respiratory infections (sinus infections).

These are not all the side effects with ENBREL. Tell your healthcare provider about any side effect that bothers you or does not go away.

Please see Prescribing Information and Medication Guide.

INDICATIONS

Moderate to Severe Rheumatoid Arthritis (RA)

Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)

ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older.

Psoriatic Arthritis

Ankylosing Spondylitis (AS)

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

Moderate to Severe Plaque Psoriasis

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The products discussed herein may have different product labeling in different countries.
Manufactured by Immunex Corporation, Thousand Oaks, CA 91320. Marketed by Amgen Inc.
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