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Indications

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone. Read More

ENBREL is indicated for chronic moderate to severe plaque psoriasis (PsO) in children 4 years and older and adults who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light). 
ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.
ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis. 
ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older. Close
What is PsO

What is
moderate to
severe plaque
psoriasis (PsO)?

What is PsO_desktop

What is moderate to severe
plaque psoriasis (PsO)?

Plaque psoriasis is a lifelong condition that causes thick, scaly, red skin. It was estimated in 2013, about 7.4 million adults in America have psoriasis. Plaque psoriasis is the most common form. Approximately 1.4 million Americans suffer from moderate to severe plaque psoriasis.

  • OVERVIEW
  • SYMPTOMS

Take a few minutes to learn more about plaque psoriasis.

  • What's going on inside your body?

    Illustration of plaque psoriasis in the body Illustration of plaque psoriasis in the body

    Your immune system is designed to help protect your body from bacteria, infection, and viruses. But in conditions like plaque psoriasis, your immune system is not working properly. It could make too much of several proteins, including one called tumor necrosis factor, or TNF. The extra TNF can cause inflammation. This leads to skin cell buildup and the formation of raised red patches, known as plaques, which often have silvery tops.

    See what ENBREL does in response.
  • What are some symptoms of plaque psoriasis?

    Plaque psoriasis on skin Plaque psoriasis on skin

    Most people see patches of thick red skin with silvery scales on top. These are called plaques. They can appear anywhere, but are often seen on the elbows, knees, head, and lower back. Some people also have joint pain. If you have both joint and skin symptoms, you may have a related condition called psoriatic arthritis. It’s important to tell your doctor about all your symptoms so that you can get the best treatment possible.

  • What can make symptoms worse?

    Man driving appears to be stressed out Man driving appears to be stressed out

    Plaque psoriasis symptoms may get better or worse without reason. But some events can trigger flare-ups. Stress, skin injuries, infections, or reactions to some medicines are a few things that may make your plaque psoriasis get worse.

  • Who gets plaque psoriasis and why?

    Couple gazing Couple gazing

    People of all ages, sexes, and ethnicities can get plaque psoriasis. The peak ages of onset are between 20-30 and 50-60 years of age. No one knows the exact cause, but it can be passed from one generation to the next.

Plaque psoriasis:
what you should know

The symptoms of plaque psoriasis can sometimes be mistaken for other skin conditions. To help your doctor find the best treatment for you, it’s important to understand your symptoms. The main symptom of plaque psoriasis is plaques on the skin.

What are plaques?

Patches of thick red skin with silvery scales on top

Plaques can be anywhere on the skin

Most plaques are on the elbows, knees, head, or lower back


If you also have joint pain, swelling, or morning stiffness, be sure to tell your doctor. Having both joint and skin symptoms may mean you have a different condition called psoriatic arthritis.

Plaques can appear anywhere on the body. Symptoms also seem to get better or worse without reason. But there are certain events that are known to cause flare-ups, such as stress, skin injuries, infections, or reactions to some medicines.

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Doctor Discussion Guide

Use this simple guide to help your doctor understand how your moderate to severe PsO is impacting your life, and ask whether ENBREL is right for you.

Download the Doctor Discussion Guide  »
+ See More

Important Safety Information

What is the most important information I should know about ENBREL?

ENBREL is a medicine that affects your immune

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections
have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have

 
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Prescription Enbrel® (etanercept) is taken (given) by injection.

Important Safety Information

What is the most important information I should know about ENBREL?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your healthcare provider should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.

There have been some cases of unusual cancers, some resulting in death, reported in children and teenage patients who started using tumor necrosis factor (TNF) blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA may be more likely to get lymphoma.

Before starting ENBREL, tell your healthcare provider if you:

  • Have any existing medical conditions
  • Are taking any medicines, including herbals
  • Think you have, are being treated for, have signs of, or are prone to infection. You should not start taking ENBREL if you have any kind of infection, unless your healthcare provider says it is okay
  • Have any open cuts or sores
  • Have diabetes, HIV, or a weak immune system
  • Have TB or have been in close contact with someone who has had TB
  • Were born in, lived in, or traveled to countries where there is more risk for getting TB. Ask your healthcare provider if you are not sure
  • Live, have lived in, or traveled to certain parts of the country (such as, the Ohio and Mississippi River valleys, or the Southwest) where there is a greater risk for certain kinds of fungal infections, such as histoplasmosis. These infections may develop or become more severe if you take ENBREL. If you don’t know if these infections are common in the areas you’ve been to, ask your healthcare provider
  • Have or have had hepatitis B
  • Have or have had heart failure
  • Develop symptoms such as persistent fever, bruising, bleeding, or paleness while taking ENBREL
  • Use the medicine Kineret (anakinra), Orencia (abatacept), or Cytoxan (cyclophosphamide)
  • Are taking anti-diabetic medicines
  • Have, have had, or develop a serious nervous disorder, seizures, any numbness or tingling, or a disease that affects your nervous system such as multiple sclerosis or Guillain-Barré syndrome
  • Are scheduled to have surgery
  • Have recently received or are scheduled for any vaccines. All vaccines should be brought up-to-date before starting ENBREL. Patients taking ENBREL should not receive live vaccines.
  • Are allergic to rubber or latex
  • Are pregnant, planning to become pregnant, or breastfeeding
  • Have been around someone with chicken pox

What are the possible side effects of ENBREL?

ENBREL can cause serious side effects including: New infections or worsening of infections you already have; hepatitis B can become active if you already have had it; nervous system problems, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes; blood problems (some fatal); new or worsening heart failure; new or worsening psoriasis; allergic reactions; autoimmune reactions, including a lupus-like syndrome and autoimmune hepatitis.

Common side effects include: Injection site reactions and upper respiratory infections (sinus infections).

In general, side effects in children were similar in frequency and type as those seen in adult patients. The types of infections reported were generally mild and similar to those usually seen in children.

These are not all the side effects with ENBREL. Tell your healthcare provider about any side effect that bothers you or does not go away.

If you have any questions about this information, be sure to discuss them with your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Prescribing Information and Medication Guide.

Indications

Moderate to Severe Rheumatoid Arthritis (RA)

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.

Psoriatic Arthritis

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.

Moderate to Severe Plaque Psoriasis

ENBREL is indicated for chronic moderate to severe plaque psoriasis (PsO) in children 4 years and older and adults who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light).

Ankylosing Spondylitis (AS)

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)

ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older.

References: 1. Parsabiv® (etelcalcetide) prescribing information, Amgen. 2. Data on file, Amgen; [Summary of Clinical Efficacy; 2015]. 3. Alexander ST, et al. Mol Pharmacol. 2015;88:853-865. 4. Data on file, Amgen; [Report R20130052, 2014]. 5. Chen P, et al. CPT Pharmacometrics Syst Pharmacol. 2016;5:484-494. 6. Sensipar® (cinacalcet) prescribing information, Amgen. 7. Ma JN, et al. J Pharmacol Exp Ther. 2011;337:275-284.
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