Did you know joint
pain and joint
damage can go
side by side?

Controlling joint pain can help you get back to doing the things you enjoy. But joint pain and joint damage can go side by side in patients with moderate to severe rheumatoid arthritis (RA) and psoriatic arthritis.

The good news is that biologic medicines like Enbrel® (etanercept) can help relieve joint pain and help stop further damage.

What do you know about joint health?

Test your knowledge with the quiz below.

TAKETHEQUIZ

QUESTION 1 OF 5

If you’re on treatment for RA and your pain is controlled, you can't have ongoing joint damage:

INCORRECT. The answer is false

Ongoing joint damage can happen even when you’re not in pain—and that damage is permanent. In moderate to severe RA, ENBREL not only reduces joint pain, but it can also help block the inflammation that leads to permanent joint damage.

QUESTION 2 OF 5

Rheumatoid arthritis and psoriatic arthritis are:

INCORRECT. The answer is diseases of the immune system

In these types of arthritis, the immune system overproduces certain proteins, which cause inflammation, and that inflammation causes the pain and swelling in your joints. This inflammation causes joint damage in patients with RA and in about 57% of people diagnosed with psoriatic arthritis. You can work with your doctor to better understand your condition.

QUESTION 3 OF 5

Psoriatic arthritis is associated with:

INCORRECT. The answer is all of the above

Psoriatic arthritis can cause skin plaques and joint pain, swelling in the fingers and toes, and back pain. Skin plaques may be thick and red, sometimes with silvery scales on top.

QUESTION 4 OF 5

Women are more likely than men to develop rheumatoid arthritis:

INCORRECT. The answer is true

Women make up 70% of rheumatoid arthritis patients. The condition usually appears in people 35 to 50 years old, but can occur at any age.

QUESTION 5 OF 5

Which of the following are commonly used treatments for moderate to severe rheumatoid arthritis?

INCORRECT. The answer is all of the above

NSAIDs, DMARDs, and biologics are all commonly used treatments for moderate to severe rheumatoid arthritis. ENBREL is a biologic that helps to relieve joint pain and stiffness and block the inflammation that causes joint damage.

Done! You got 0 out of 5 right.

Want to test your knowledge again? Retake the quiz. Or scroll down to get more facts and visit our website to learn more about treating joint pain and joint damage.

Find out more about ENBREL for:

FACTS. FROM PHIL

Hear facts about joint pain from Phil Mickelson, Pro Golfer and ENBREL Patient.

FACT vs. FICTION

Inflammation in knee joint

FACT.

Not all joint pain is “just arthritis”

Inflammation in knee joint

While you may feel pain in your joints, certain types of arthritis such as rheumatoid arthritis (RA) and psoriatic arthritis are actually conditions of the immune system, not only of the joints themselves. In people with these conditions, the immune system sends out signals triggering the creation of too much of several proteins, including one called tumor necrosis factor or TNF. Too much TNF is one of the causes of inflammation, which leads to the pain and swelling associated with these arthritis conditions. Learn more about how ENBREL works to treat RA and psoriatic arthritis.

FACT.

A rheumatologist may be able to help if you have psoriatic arthritis

Talking to a rheumatologist

The link between RA and joint damage is well known, but studies show that about 57% of patients with psoriatic arthritis have joint damage too. Although joint damage can’t be reversed, there are treatments that can help stop the damage from getting worse. That’s why it’s so important to talk to your doctor about your joint pain as soon as you can. You may want to consider seeing a rheumatologist, a physician who specializes in joint conditions. A rheumatologist has advanced knowledge of these diseases, and can prescribe a biologic like ENBREL that helps to relieve joint pain and help stop joint damage from getting worse if you have psoriatic arthritis or moderate to severe rheumatoid arthritis.

Find a rheumatologist now

Talking to a rheumatologist
Rheumatoid arthritis or psoriatic arthritis symptom flares

FACT.

Some patients find that a number of things may trigger a flare up

Rheumatoid arthritis or psoriatic arthritis symptom flares

Triggers can cause you to experience “flares,” periods when your RA or psoriatic arthritis symptoms are more active. For patients with rheumatoid arthritis, common triggers can include certain foods, injuries to the skin, air pollution like cigarette smoke, and infections. With psoriatic arthritis, triggers that have been associated with skin symptom flares include stress, infections, injuries to the skin or reactions to some medicines. Some people seem to have different triggers. Your rheumatologist can help you create a plan to reduce exposure to the triggers that may affect you.

FICTION.

You can stop treatment once your symptoms improve

Working with your rheumatologist

You may consider going off treatment once your RA or psoriatic arthritis symptoms are successfully controlled. Keep in mind that many patients see their symptoms return or may be at risk for further joint damage after they stop treating their condition. You should always consult with your physician before making changes to your treatment.

Working with your rheumatologist
Enbrel (etanercept) in knee

FACT.

Not all arthritis medicines treat the condition in the same way

Enbrel (etanercept) in knee

In moderate to severe rheumatoid arthritis and psoriatic arthritis, the goal of treatment is to help relieve pain and swelling and prevent joint damage. In patients with psoriatic arthritis, physicians also seek to treat skin symptoms like red, scaly plaques.

Doctors sometimes suggest using nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen to help ease swelling and relieve joint pain. These treatments only help relieve these symptoms, but they are not proven to help limit further joint damage.

Some rheumatologists will prescribe disease-modifying anti-rheumatic drugs (DMARDs), which work on the immune system. Methotrexate is one of the most common DMARDs, but many people find that methotrexate alone is not always enough to relieve their symptoms.

For patients with certain types of arthritis, like RA or psoriatic arthritis, doctors may prescribe biologic medicines. When you have certain types of arthritis, your immune system isn’t working properly and sends signals that cause inflammation that leads to joint pain and swelling.

ENBREL is the #1 biologic prescribed by rheumatologists.* It works on your immune system to help block the signals that cause joint pain and swelling, and stop joint damage from getting worse.

Because ENBREL works on your immune system, it can make it harder to fight infections, such as the flu.

Find out if ENBREL is right for you I live with RA I live with psoriatic arthritis

Read moreless

* 6-month average of IMS monthly NPA prescription data by rheumatologists. IMS NPA prescription data does not include products administered by infusion.

See how
ENBREL works

ENBREL helps to relieve joint pain, swelling, and stiffness in people with moderate to severe RA and can help to reduce fatigue or tiredness. It also helps stop joint damage from getting worse.

guides
guides

Make sure you’re asking questions about your joint pain

This customizable Appointment Guide can help you talk to your rheumatologist about your condition.

Please see the full Prescribing Information, Important Safety Information, and Medication Guide for more details about ENBREL.

Prescription Enbrel® (etanercept) is taken by injection.

IMPORTANT SAFETY INFORMATION
What is the most important information I should know about ENBREL?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your healthcare provider should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.

There have been some cases of unusual cancers reported in children and teenage patients who started using tumor necrosis factor (TNF) blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA may be more likely to get lymphoma.

Before starting ENBREL, tell your healthcare provider if you:
  • Have any existing medical conditions
  • Are taking any medicines, including herbals
  • Think you have, are being treated for, have signs of, or are prone to infection. You should not start taking ENBREL if you have any kind of infection, unless your healthcare provider says it is okay
  • Have any open cuts or sores
  • Have diabetes, HIV, or a weak immune system
  • Have TB or have been in close contact with someone who has had TB
  • Were born in, lived in, or traveled to countries where there is more risk for getting TB. Ask your healthcare provider if you are not sure
  • Live, have lived in, or traveled to certain parts of the country (such as, the Ohio and Mississippi River valleys, or the Southwest) where there is a greater risk for certain kinds of fungal infections, such as histoplasmosis. These infections may develop or become more severe if you take ENBREL. If you don’t know if these infections are common in the areas you’ve been to, ask your healthcare provider
  • Have or have had hepatitis B
  • Have or have had heart failure
  • Develop symptoms such as persistent fever, bruising, bleeding, or paleness while taking ENBREL
  • Use the medicine Kineret® (anakinra), Orencia® (abatacept), or Cytoxan® (cyclophosphamide)
  • Are taking anti-diabetic medicines
  • Have, have had, or develop a serious nervous disorder, seizures, any numbness or tingling, or a disease that affects your nervous system such as multiple sclerosis or Guillain-Barré syndrome
  • Are scheduled to have surgery
  • Have recently received or are scheduled for any vaccines. All vaccines should be brought up-to-date before starting ENBREL. Patients taking ENBREL should not receive live vaccines.
  • Are allergic to rubber or latex
  • Are pregnant, planning to become pregnant, or breastfeeding
  • Have been around someone with chicken pox
What are the possible side effects of ENBREL?

ENBREL can cause serious side effects including: New infections or worsening of infections you already have; hepatitis B can become active if you already have had it; nervous system problems, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes; blood problems (some fatal); new or worsening heart failure; new or worsening psoriasis; allergic reactions; autoimmune reactions, including a lupus-like syndrome and autoimmune hepatitis.

Common side effects include: Injection site reactions and upper respiratory infections (sinus infections).

In general, side effects in children were similar in frequency and type as those seen in adult patients. The types of infections reported were generally mild and similar to those usually seen in children.

These are not all the side effects with ENBREL. Tell your healthcare provider about any side effect that bothers you or does not go away.

If you have any questions about this information, be sure to discuss them with your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Prescribing Information and Medication Guide.

INDICATIONS
Moderate to Severe Rheumatoid Arthritis (RA)

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.

Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)

ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older.

Psoriatic Arthritis

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.

Ankylosing Spondylitis (AS)

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

Moderate to Severe Plaque Psoriasis

ENBREL is indicated for chronic moderate to severe plaque psoriasis (PsO) in children 4 years and older and adults who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light).

IMPORTANT SAFETY INFORMATION
What is the most important information I should know about ENBREL?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your healthcare provider should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.

There have been some cases of unusual cancers reported in children and teenage patients who started using tumor necrosis factor (TNF) blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA may be more likely to get lymphoma.

Before starting ENBREL, tell your healthcare provider if you:
  • Have any existing medical conditions
  • Are taking any medicines, including herbals
  • Think you have, are being treated for, have signs of, or are prone to infection. You should not start taking ENBREL if you have any kind of infection, unless your healthcare provider says it is okay
  • Have any open cuts or sores
  • Have diabetes, HIV, or a weak immune system
  • Have TB or have been in close contact with someone who has had TB
  • Were born in, lived in, or traveled to countries where there is more risk for getting TB. Ask your healthcare provider if you are not sure
  • Live, have lived in, or traveled to certain parts of the country (such as, the Ohio and Mississippi River valleys, or the Southwest) where there is a greater risk for certain kinds of fungal infections, such as histoplasmosis. These infections may develop or become more severe if you take ENBREL. If you don’t know if these infections are common in the areas you’ve been to, ask your healthcare provider
  • Have or have had hepatitis B
  • Have or have had heart failure
  • Develop symptoms such as persistent fever, bruising, bleeding, or paleness while taking ENBREL
  • Use the medicine Kineret® (anakinra), Orencia® (abatacept), or Cytoxan® (cyclophosphamide)
  • Are taking anti-diabetic medicines
  • Have, have had, or develop a serious nervous disorder, seizures, any numbness or tingling, or a disease that affects your nervous system such as multiple sclerosis or Guillain-Barré syndrome
  • Are scheduled to have surgery
  • Have recently received or are scheduled for any vaccines. All vaccines should be brought up-to-date before starting ENBREL. Patients taking ENBREL should not receive live vaccines.
  • Are allergic to rubber or latex
  • Are pregnant, planning to become pregnant, or breastfeeding
  • Have been around someone with chicken pox
What are the possible side effects of ENBREL?

ENBREL can cause serious side effects including: New infections or worsening of infections you already have; hepatitis B can become active if you already have had it; nervous system problems, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes; blood problems (some fatal); new or worsening heart failure; new or worsening psoriasis; allergic reactions; autoimmune reactions, including a lupus-like syndrome and autoimmune hepatitis.

Common side effects include: Injection site reactions and upper respiratory infections (sinus infections).

In general, side effects in children were similar in frequency and type as those seen in adult patients. The types of infections reported were generally mild and similar to those usually seen in children.

These are not all the side effects with ENBREL. Tell your healthcare provider about any side effect that bothers you or does not go away.

If you have any questions about this information, be sure to discuss them with your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Prescribing Information and Medication Guide.

INDICATIONS
Moderate to Severe Rheumatoid Arthritis (RA)

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.

Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)

ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older.

Psoriatic Arthritis

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.

Ankylosing Spondylitis (AS)

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

Moderate to Severe Plaque Psoriasis

ENBREL is indicated for chronic moderate to severe plaque psoriasis (PsO) in children 4 years and older and adults who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light).

  • Close
IMPORTANT SAFETY INFORMATION: What is the most important information I should know about Enbrel® (etanercept)?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis(TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your healthcare provider should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.

There have been some cases of unusual cancers reported in children and teenage patients who started using tumor necrosis factor (TNF) blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA may be more likely to get lymphoma.

Before starting ENBREL, tell your healthcare provider if you:

  • Have any existing medical conditions
  • Are taking any medicines, including herbals
  • Think you have, are being treated for, have signs of, or are prone to infection. You should
    not start taking ENBREL if you have any kind of infection, unless your healthcare provider says it is
    okay
  • Have any open cuts or sores
  • Have diabetes, HIV, or a weak immune system
  • Have TB or have been in close contact with someone who has had TB
  • Were born in, lived in, or traveled to countries where there is more risk for getting TB. Ask
    your healthcare provider if you are not sure
  • Live, have lived in, or traveled to certain parts of the country (such as, the Ohio and
    Mississippi River valleys, or the Southwest) where there is a greater risk for certain kinds of
    fungal infections, such as histoplasmosis. These infections may develop or become more
    severe if you take ENBREL. If you don’t know if these infections are common in the areas you’ve
    been to, ask your healthcare provider
  • Have or have had hepatitis B
  • Have or have had heart failure
  • Develop symptoms such as persistent fever, bruising, bleeding, or paleness while taking
    ENBREL
  • Use the medicine Kineret® (anakinra), Orencia® (abatacept), or Cytoxan®
    (cyclophosphamide)
  • Are taking anti-diabetic medicines
  • Have, have had, or develop a serious nervous disorder, seizures, any numbness or tingling,
    or a disease that affects your nervous system such as multiple sclerosis or Guillain-Barré
    syndrome
  • Are scheduled to have surgery
  • Have recently received or are scheduled for any vaccines. All vaccines should be brought
    up-to-date before starting ENBREL. Patients taking ENBREL should not receive live
    vaccines.
  • Are allergic to rubber or latex
  • Are pregnant, planning to become pregnant, or breastfeeding
  • Have been around someone with chicken pox
What are the possible side effects of ENBREL?

ENBREL can cause serious side effects including: New infections or worsening of infections
you already have; hepatitis B can become active if you already have had it; nervous system
problems
, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes;
blood problems (some fatal); new or worsening heart failure; new or worsening psoriasis;
allergic reactions; autoimmune reactions, including a lupus-like syndrome and autoimmune
hepatitis.

Common side effects include: Injection site reactions, upper respiratory infections (sinus
infections), and headache.

In general, side effects in children were similar in frequency and type as those seen in adult patients. The types of infections reported were generally mild and similar to those usually seen in children.

These are not all the side effects with ENBREL. Tell your healthcare provider about any side effect that
bothers you or does not go away.

If you have any questions about this information, be sure to discuss them with your healthcare provider.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit
www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Prescribing Information and Medication Guide.

INDICATIONS
Moderate to Severe Rheumatoid Arthritis (RA)

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting
worse, and improving physical function in patients with moderately to severely active rheumatoid
arthritis. ENBREL can be taken with methotrexate or used alone.

Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)

ENBREL is indicated for reducing signs and symptoms of moderately to severely active
polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older.

Psoriatic Arthritis

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting
worse, and improving physical function in patients with psoriatic arthritis. ENBREL can be
used with or without methotrexate.

Ankylosing Spondylitis(AS)

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing
spondylitis.

Moderate to Severe Plaque Psoriasis

ENBREL is indicated for chronic moderate to severe plaque psoriasis (PsO) in children 4 years and older and adults ages who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light).



At Enbrel.com, you can learn about Enbrel® (etanercept), a self-injected biologic medicine
used to treat inflammatory diseases with long-term effects. You can find information about
moderate to severe rheumatoid arthritis(RA), moderate to severe plaque psoriasis, psoriatic
arthritis, moderately to severely active polyarticular juvenile idiopathic arthritis(JIA), and
ankylosing spondylitis(AS). You can learn about symptoms, treatment, how Enbrel®
(etanercept) works for each condition, results for each condition, results for each condition, and safety information.

Enbrel.com supports you and your loved ones from diagnosis to treatment. You can find
resources like injection demonstrations, patient testimonial videos, questions to ask your
doctor, and even help with finding a rheumatologist or dermatologist near you.

Enbrel.com also provices ongoing assistance with ENBREL SupportTM, a patient support
program to help with out-of-pocket costs and connect you with registered nurses and
ENBREL Nurse Partners. The resources available will help you get started. Resources
include the ENBREL Starter Kit, injection and medicine refill reminders, free needle disposal
containers, travel packs, and ongoing education.

  • See More
  • See More
IMPORTANT SAFETY INFORMATION:
What is the most important information I should know about Enbrel® (etanercept)?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your healthcare provider should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.