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for Polyarticular Juvenile Idiopathic Arthritis 
Polyarticular JIA is a subset of the most common type of arthritis affecting children. JIA affects 5 or more joints, with pain lasting for more than 6 weeks. It begins before the age of 16.
Take a few minutes to learn more about polyarticular JIA.
The immune system is designed to help protect the body from many harmful things. But if, for unknown reasons, the immune system doesn’t work right, it can make your child sick. In polyarticular JIA, cells from your child’s immune system move into the joints. These cells make several proteins that can cause swelling and pain. One of these proteins is called tumor necrosis factor, or TNF. Too much TNF may lead to inflammation. Inflammation is what causes the pain, swelling, and stiffness of your child’s joints over time.
See what ENBREL does in response.Most children with polyarticular JIA feel pain or stiffness when moving joints, especially in the morning. Polyarticular JIA affects 5 or more joints. There are other symptoms as well. Some children have joints that feel warm or tender. Others say that it gets harder to move around and do daily activities. Swelling in the joints is also common.
Polyarticular JIA can affect any child at any age. Polyarticular JIA affects girls 2 to 4 times as often as boys, and it begins before the age of 16.
Polyarticular JIA symptoms can progress over time. That’s why it’s important to talk to your child’s doctor and find the best way to manage your child’s condition.
Download an ENBREL Appointment Guide.
Every child with polyarticular JIA may not have all the same symptoms. But your child's doctor will look for these common symptoms to help reach a diagnosis:
Joint pain or stiffness when moving joints
Stiffness in the morning or after resting
Warm or tender joints
Limited range of motion (your child's ability to move his or her joints)
Swelling in the joints
A rheumatologist might also use blood tests and X-rays to look for additional signs of JIA.
Polyarticular JIA affects 5 or more joints during the first 6 months. It’s important to talk to a rheumatologist to find the best way to manage your child’s condition.
Use this simple guide to help your child's doctor understand how moderate to severe polyarticular JIA is impacting your child's life, and ask whether ENBREL is right for your child.
Download the Doctor Discussion Guide »
Download our JIA Brochure, which has information for your child in one place.
Download Now »ENBREL is a medicine that affects your immune
ENBREL is a medicine that affects your immune system. ENBREL can
lower the ability of your immune system to fight infections. Serious infections
have happened in patients taking ENBREL. These infections include tuberculosis (TB) and
infections caused by viruses, fungi, or bacteria
that have
What is the most important information I should know about ENBREL?
ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your healthcare provider should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.
There have been some cases of unusual cancers, some resulting in death, reported in children and teenage patients who started using tumor necrosis factor (TNF) blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA may be more likely to get lymphoma.
Before starting ENBREL, tell your healthcare provider if you:
What are the possible side effects of ENBREL?
ENBREL can cause serious side effects including: New infections or worsening of infections you already have; hepatitis B can become active if you already have had it; nervous system problems, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes; blood problems (some fatal); new or worsening heart failure; new or worsening psoriasis; allergic reactions; autoimmune reactions, including a lupus-like syndrome and autoimmune hepatitis.
Common side effects include: Injection site reactions and upper respiratory infections (sinus infections).
In general, side effects in children were similar in frequency and type as those seen in adult patients. The types of infections reported were generally mild and similar to those usually seen in children.
These are not all the side effects with ENBREL. Tell your healthcare provider about any side effect that bothers you or does not go away.
If you have any questions about this information, be sure to discuss them with your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please see Prescribing Information and Medication Guide.
Moderate to Severe Rheumatoid Arthritis (RA)
ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.
Psoriatic Arthritis
ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.
Moderate to Severe Plaque Psoriasis
ENBREL is indicated for chronic moderate to severe plaque psoriasis (PsO) in children 4 years and older and adults who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light).
Ankylosing Spondylitis (AS)
ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.
Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)
ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older.
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