About Moderate to Severe Plaque Psoriasis

Once diagnosed, plaque psoriasis a lifelong disease involving the immune system that causes red, scaly patches to appear on the skin. There are multiple types of psoriasis, including plaque, guttate, inverse, pustular and erythrodermic. Plaque psoriasis is the most common form of psoriasis. Approximately 1.5 million Americans suffer from moderate to severe plaque psoriasis.

Plaque psoriasis is a disease of the immune system

While plaque psoriasis may look like just a skin condition, it is in fact a disease of the immune system. The immune system protects the body from infections and diseases. In patients with plaque psoriasis, certain immune cells are activated and play an important role. They overproduce inflammatory proteins such as tumor necrosis factor (TNF). These proteins can cause skin cells to grow too quickly. The skin cells build up and form raised, red patches often with a silvery scale, known as plaques. These plaques may itch, be painful, and can bleed. Knowing how plaque psoriasis develops—from inside the body—can help you understand how some treatments, like ENBREL, can help. Get a closer look at how ENBREL works.

What does a plaque look like?

Plaques are raised, red patches often with a silvery scale.
This is an example of what plaques look like. Plaques are raised, red patches, often with a silvery scale.
Example of one skin area.

Symptoms of plaque psoriasis

Plaque psoriasis causes raised red patches with a silvery scale to appear on the skin. They can appear anywhere on the body, but are most commonly found on the elbows, knees, scalp, and lower back. People with plaque psoriasis may notice that there are times when their skin worsens, then gets better. Factors that cause these "flare-ups" can include:

  • emotional stress
  • injury to the skin
  • some types of infections
  • reactions to certain drugs

How plaque psoriasis can be treated

There is no cure for plaque psoriasis, but there are a variety of treatments that can help clear the skin. Biologics work inside your body to treat psoriasis at the source. ENBREL is a prescription medicine that is self-injected. ENBREL, a biologic, blocks the activity of excess TNF that is associated with plaque psoriasis. This helps slow the growth of skin cells before they cause plaques to appear on the skin. Learn more about results with ENBREL. Because ENBREL works on your immune system, it can lower your ability to fight infections and may raise other safety concerns. If you have any sign of an infection including a fever, cough, flu-like symptoms, or have any open sores on your body, call your doctor. Please see Prescribing Information, Important Safety Information, and Medication Guide for complete details about ENBREL.

Prescription ENBREL is taken by injection.


Moderate to Severe Plaque Psoriasis
ENBREL is indicated for the treatment of adult patients (18 years or older) with chronic moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

Supportive data
Moderate to Severe Plaque Psoriasis
  • In medical studies, nearly half of patients saw 75% skin clearance in 3 months. Overall, 3 out of 4 patients saw 50% skin clearance in 3 months.
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Are you experiencing
joint pain?

If you have skin plaques and are also feeling pain, stiffness, or swelling in your joints, you may have a condition called psoriatic arthritis. Talk to your doctor.