ENBREL Dosing for Moderately to Severely Active Juvenile Idiopathic Arthritis (JIA)

ENBREL is taken by injection and might fit easily into your child's schedule. Your child's doctor will tell you how often he or she should use ENBREL. The weekly dose of ENBREL depends on your child's weight. The prescribing doctor will tell you which form of ENBREL to use and how much to give your child.

Juvenile idiopathic arthritis dosing

The recommended dose of ENBREL for pediatric patients ages 2 to 17 years with moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) is 0.8 mg/kg per week (up to a maximum of 50 mg per week). For pediatric patients weighing 63 kg (138 pounds) or more, the weekly dose of 50 mg may be given using Enbrel® SureClick® autoinjectors or prefilled syringes. For pediatric patients weighing 31 kg to 62 kg (68 pounds to 136 pounds) the total weekly dose should be given as two subcutaneous (an injection beneath the skin) injections, either on the same day or 3 or 4 days apart. The dose for pediatric patients weighing less than 31 kg (68 pounds) should be given as a single subcutaneous injection once weekly using the correct volume from the free-hand vial.

Do NOT use ENBREL more often than prescribed. Make sure your child does not miss any doses of ENBREL. Call your child's doctor if he or she misses a dose to find out when to give your child the next injection.

Injection site reactions such as redness, rash, swelling, itching, or bruising may occur. These symptoms usually go away within 3 to 5 days. If your child experiences these reactions and they get worse or don't go away, call your child's doctor. Please see Prescribing Information, Important Safety Information, and Medication Guide for complete details about ENBREL.

Tip: Set aside specific times every week to prepare and give your child the injection of ENBREL.

Need injection help?

Watch easy-to-follow videos and see how others self-inject ENBREL.

Prescription ENBREL is taken by injection.


Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)
ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older.

Supportive data
Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)
  • In a clinical study, ENBREL was shown to be effective in about 3 out of 4 children with JIA who used it at 3 months. ENBREL has been shown to begin working in as few as 2 to 4 weeks.
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