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Injection Options and Demos

ENBREL is injected just under the skin. ENBREL should be injected in the front of the middle thighs, the stomach (avoiding the 2-inch area around the belly button), or the outer area of the upper arms. With the design of the Enbrel® (etanercept) SureClick® autoinjector, you'll never even have to see the needle.


Before starting ENBREL, tell your doctor if you think you have an infection, or if you have a fever, cough, flu-like symptoms, or an open sore. Do NOT start ENBREL if you have any kind of infection. While taking ENBREL, call your doctor immediately if you have an infection as ENBREL can increase your risk of infection.

Multiple injection options

ENBREL offers the convenience and flexibility of multiple administration options. Choose the method you are most comfortable with or one that is recommended by your doctor:

  • Enbrel® SureClick® 50-mg/mL autoinjector
  • ENBREL single-use prefilled syringe
  • ENBREL 25-mg multi-use vial free-hand method
  • ENBREL 25-mg vial adapter method

Step-by-step injection demos

You or a caregiver should receive training from your health care professional for the first injection of ENBREL in the doctor's office. After the training, you can self-inject ENBREL in the comfort of your home. Click below to view step-by-step instructions.

Injection site reactions such as redness, rash, swelling, itching, or bruising may occur. On average, these symptoms go away within 3 to 5 days. If you experience these reactions and they don't go away or get worse, call your doctor.

Patients can inject ENBREL using a 50 mg/mL prefilled autoinjector.

Enbrel® SureClick®
50-mg/mL autoinjector


Patients can inject ENBREL using a 50-mg/mL prefilled autoinjector, after receiving instructions from their healthcare provider. The Enbrel® SureClick® autoinjector is for a single use only.

Chapter 1: Preparation

Chapter 2: Prepping the Injection Site

Chapter 3: Injection Steps

Chapter 4: Disposal

Patients can inject ENBREL using a 50 mg/mL and 25 mg/mL prefilled syringe.

ENBREL single-use prefilled syringe


Patients can inject ENBREL using a prefilled syringe available in 50-mg/mL and 25-mg/0.5-mL dosage strengths, after receiving instructions from their healthcare provider. The prefilled syringe is for a single use only.

Chapter 1: Preparation

Chapter 2: Set Up

Chapter 3: Prepping the Injection Site

Chapter 4: Checking the Needle

Chapter 5: Injecting ENBREL

Chapter 6: Disposal

For children with juvenile idiopathic arthritis (JIA), caregivers can use the multi-use vial free-hand method.

ENBREL 25-mg multi-use vial free-hand method


For some children with juvenile idiopathic arthritis (JIA), one vial of ENBREL solution can be used for more than one dose. The free-hand method should be used for these children, after receiving instructions from their healthcare provider.

Step 1: Setting Up

Step 2: Preparing the ENBREL Solution

Step 3: Withdrawing the Solution

Step 4: Preparing for Injection

Step 5: Injecting ENBREL

Step 6: Disposal

People who use a single vial of ENBREL for each dose may use the vial adapter device to assist with mixing and withdrawing ENBREL, after receiving instructions from their healthcare provider.

ENBREL 25-mg vial adapter method


People who use a single vial of ENBREL for each dose may use the vial adapter device to assist with mixing and withdrawing ENBREL, after receiving instructions from their healthcare provider.

Step 1: Setting Up

Step 2: Preparing the ENBREL Solution

Step 3: Withdrawing the Solution

Step 4: Preparing for Injection

Step 5: Injecting ENBREL

Step 6: Disposal


Please see Instructions for Use.

Please see Prescribing Information, Important Safety Information, and Medication Guide for complete details about ENBREL.

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are available 8 AM to 8 PM (ET), Monday through Friday. Live support is available in over 200 languages. If this is a medical emergency, please call 911.
Please only request this call regarding your treatment or the treatment of a child in your care.

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Prescription ENBREL is taken by injection.

IMPORTANT SAFETY INFORMATION
Indications

Moderate to Severe Rheumatoid Arthritis (RA)
ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderate to severe rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.

Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)
ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older.

Psoriatic Arthritis
ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with psoriatic arthritis. ENBREL can be used in combination with methotrexate in patients who do not respond adequately to methotrexate alone.

Ankylosing Spondylitis (AS)
ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

Moderate to Severe Plaque Psoriasis
ENBREL is indicated for the treatment of adult patients (18 years or older) with chronic moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

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7 days a week

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