How ENBREL Works
Plaque psoriasis and psoriatic arthritis are diseases of the
immune system. In patients with plaque psoriasis and psoriatic arthritis, certain immune cells
are activated and produce too much active
tumor necrosis factor (TNF). This protein causes inflammation in the skin, which can cause skin cells to grow too quickly. The skin cells build up and form raised, red patches, often with silvery scales, known as psoriatic lesions. These plaques may itch, be
painful, and can bleed. This protein also causes inflammation in the joints, which can create pain and progressive joint damage.
Targeting the source
Biologic therapies like ENBREL actually target the source of psoriatic skin
symptoms and can help lessen the joint pain and help stop the progressive joint
damage associated with psoriatic arthritis.
ENBREL blocks the activity of excess TNF to reduce the inflammation that causes psoriatic lesions
and joint pain. Because ENBREL works on your immune system, it may lower the ability of your
immune system to fight infections and may raise other safety concerns. If you have any sign of an infection including a fever, cough, flu-like
symptoms, or have any open sores on your body, call your doctor.
Please see Full Prescribing Information, Important Safety Information, and Medication Guide for complete details about ENBREL.
Watch this short video, in which Dr. Craig Leonardi explains how plaque psoriasis is a disease of the immune system and describes how ENBREL works. See how ENBREL targets the immune system to reduce the overproduction of skin cells to help you get clearer skin.