ENBREL Dosing for Ankylosing Spondylitis (AS)

ENBREL is an injection that might fit easily into your schedule. Your doctor will tell you how often you should use ENBREL. Do NOT use ENBREL more often than prescribed.

Ankylosing spondylitis dosing

The recommended dose of ENBREL for adult patients with ankylosing spondylitis (AS) is 50 mg per week. A 50 mg dose can be given as one subcutaneous injection (an injection beneath the skin) using either a 50 mg/mL Enbrel® SureClick® autoinjector or a 50 mg/mL single-use prefilled syringe. A 50 mg dose can also be given as two 25 mg subcutaneous injections using 25 mg/0.5 mL single-use prefilled syringes or free-hand vials.

Do NOT miss any doses of ENBREL. Call your doctor if you miss a dose of ENBREL. Your doctor will tell you if and when you should take your missed dose.

Injection site reactions such as redness, rash, swelling, itching, or bruising may occur. These symptoms usually go away within 3 to 5 days. If you experience these reactions and they get worse or don't go away, call your doctor. Please see Prescribing Information, Important Safety Information, and Medication Guide for complete details about ENBREL.

Tip: Set aside specific times every week to prepare and take your injection of ENBREL.

Need injection help?

Watch easy-to-follow videos and see how others self-inject ENBREL.

Prescription ENBREL is taken by injection.


Ankylosing Spondylitis (AS)
ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

Supportive data
Ankylosing Spondylitis (AS)
  • ENBREL was shown to be effective in about 3 out of 5 adults at 6 months. Clinical responses were seen at 2 weeks in 46% of patients, with 59% of patients receiving benefit within 8 weeks.
How do I know if I have AS?

Before your next appointment with your doctor, download these questions to help guide your conversation.

Diagnosed with AS?

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