ENBREL Indications and Usage

Moderate to Severe Rheumatoid Arthritis

ENBREL is indicated for reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be initiated in combination with methotrexate or used alone.

Psoriatic Arthritis

ENBREL is indicated for reducing signs and symptoms, inhibiting the progression of structural damage of active arthritis, and improving physical function in patients with psoriatic arthritis. ENBREL can be used in combination with methotrexate in patients who do not respond adequately to methotrexate alone.

Ankylosing Spondylitis

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

Ankylosing spondylitis (AS) is a disease that causes pain and inflammation of the joints of the spine, particularly the joints between the vertebrae and also the sacroiliac joints. In many people, joints of the arms and legs can also be affected.^1,2 As the disease progresses, it can often lead the affected spinal bones to fuse together.¹ Prompt diagnosis and treatment may help manage signs and symptoms of the spine and joints.³

In a medical study, ENBREL was shown to be effective at improving signs and symptoms in about 3 out of 5 adults with AS who used it. Clinical responses were seen at 2 weeks in 46% of patients, with 59% of patients receiving benefit within 8 weeks.^2,4,5

Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis

ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis in patients ages 2 and older.

Juvenile idiopathic arthritis (JIA) is the most common type of arthritis in children. JIA is defined as persistent arthritis in one or more joints that begins before age 16 and lasts at least 6 weeks. There are three main kinds of juvenile idiopathic arthritis: polyarticular, pauciarticular, and systemic-onset. ENBREL is indicated for moderately to severely active polyarticular JIA.^4,6,7

In a medical study, ENBREL was shown to be effective in about 3 out of 4 children with JIA who used it. For these JIA patients, ENBREL has been shown to begin working in approximately 2 to 4 weeks.^4,8,9

There have been some cases of unusual cancers reported in children and teenage patients who started using TNF blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA and psoriasis may be more likely to get lymphoma.

Dosing and Administration How ENBREL Works

Supportive data

Moderate to Severe Rheumatoid Arthritis

In medical studies, ENBREL was shown to be clinically effective in about 2 out of 3 adults with moderate to severe RA at 3 months. ENBREL has been shown to begin working in as few as 2 weeks, and most patients who benefit will do so within 3 months. In another medical study, 55% of patients who were evaluated 5 years after beginning ENBREL therapy had no further progression of joint damage.

Psoriatic Arthritis

In a medical study, ENBREL was shown to be effective in about 50% of psoriatic arthritis patients at 6 months. Clinical responses were apparent at the time of the first visit (4 weeks) and were maintained through 6 months of therapy.

Important Safety Considerations

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