ENBREL gives you and your patients the flexibility of multiple subcutaneous administration options.
ENBREL should be given as one 50-mg dose subcutaneously (SC) using either a 50-mg single-use prefilled syringe or a single-use prefilled Enbrel® (etanercept) SureClick® autoinjector. A 50-mg dose can also be given as two 25-mg SC injections using 25-mg single-use prefilled syringes or multiple-use vials. Sites for injection include the thigh, abdomen, or upper arm, and should be rotated. ENBREL should never be injected into areas where the skin is tender, bruised, red, or hard.
See Instructions for Use for detailed information on injection site selection and dose administration.
If a patient or caregiver is to administer ENBREL, the patient or caregiver should be instructed in injection techniques and how to measure and administer the correct dose (see Instructions for Use). The first injection should be performed under the supervision of a qualified health care professional. The patient's or caregiver's ability to inject subcutaneously should be assessed.
Patients and caregivers should be instructed in the technique as well as proper syringe and needle disposal, and be cautioned against reuse of needles and syringes. A puncture-resistant container for disposal of needles, syringes, and autoinjectors should be used. If the 25-mg multiple-use vial is intended for multiple use, additional syringes, needles, and alcohol swabs will be required.
Patients should be monitored for injection site reactions such as redness, rash, swelling, itching, or bruising. In controlled trials in patients with plaque psoriasis, 15% of patients treated with ENBREL developed injection site reactions during the first 3 months of treatment. Injection site reactions generally occurred in the first month and subsequently decreased in frequency. The mean duration of injection site reactions was 3 to 5 days.
How-to Videos and Demos
Review and share step-by-step instructions for patients.
Patients can inject ENBREL using a 50-mg/mL prefilled autoinjector.
Enbrel® SureClick® 50 mg/mL Autoinjector
Patients can inject ENBREL using a 50-mg/mL prefilled autoinjector. The Enbrel®
autoinjector is for single-use only.
Patients can inject ENBREL using a prefilled syringe available in 50-mg/mL and 25-mg/0.5-mL dosage strengths.
ENBREL Single-Use Prefilled Syringe
Patients can inject ENBREL using a prefilled syringe available in 50-mg/mL and 25-mg/0.5-mL dosage strengths. The prefilled syringe is for single-use only.
Enbrel 25-mg Multi-Use Vial, Free-hand Method may be used for treating some children with JIA.
ENBREL 25-mg Multi-Use Vial
For some children with JIA, one vial of ENBREL solution can be used for more than one dose. The free-hand method should be used for these children. You should not use the vial adapter method if you will be using the vial more than once.
People who use a single vial of ENBREL for each dose may use the Enbrel 25-mg Vial Adapter device to assist with mixing and withdrawing ENBREL.
ENBREL 25-mg Vial Adapter Method
People who use a single vial of ENBREL for each dose may use the vial adapter device to assist with mixing and withdrawing ENBREL.