Psoriatic Arthritis Facts

Psoriatic arthritis is an inflammatory autoimmune disorder that affects the skin and both proximal and distal joints.1

  • Up to 30% of people diagnosed with psoriasis may actually have psoriatic arthritis.2-5
  • People of all ages can develop psoriatic arthritis, but the peak incidence is between 30 and 50 years of age.5
  • It has been observed that up to 57% of patients experienced joint damage by the time they were diagnosed with psoriatic arthritis.6,7
  • In up to 70% of psoriatic arthritis patients, skin symptoms precede joint symptoms.1,8
  • In psoriatic arthritis, joint symptoms generally present 10 years after skin symptoms, but both may present simultaneously.1,9

Ongoing research suggests that the pathogenesis of psoriatic arthritis is multifactorial, with the following factors playing important roles1:

  • Genetic
  • Environmental
  • Immunologic

Pathogenesis of Psoriatic Arthritis and the Role of TNF

Tumor necrosis factor (TNF) plays a role in the pathogenesis of psoriatic arthritis. TNF can either directly or indirectly:1

  • Increase migration of leukocytes into inflamed sites11
  • Stimulate production of other proinflammatory cytokines11
  • Promote cartilage destruction11

Because psoriatic arthritis can be a severe disease with significant functional impairment, early diagnosis is critical. The American Academy of Dermatology strongly encourages dermatologists to actively evaluate signs and symptoms of psoriatic arthritis at every patient visit.12

For information about the treatment guidelines from the American Academy of Dermatology, download the AAD guidelines now.

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ENBREL is indicated for reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be initiated in combination with methotrexate (MTX) or used alone.

ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis in patients ages 2 and older.

ENBREL is indicated for reducing signs and symptoms, inhibiting the progression of structural damage of active arthritis, and improving physical function in patients with psoriatic arthritis. ENBREL can be used in combination with methotrexate in patients who do not respond adequately to methotrexate alone.

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

ENBREL is indicated for the treatment of adult patients (18 years or older) with chronic moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

Supportive data

Moderate to Severe Plaque Psoriasis
In medical studies, nearly half of patients saw 75% skin clearance in their moderate to severe plaque psoriasis in 3 months with ENBREL. Overall, 3 out of 4 patients saw 50% skin clearance in 3 months. ENBREL can work fast; many patients saw improvement within 2 months. Your results may vary.

Psoriatic Arthritis
In a medical study, ENBREL was shown to be effective in about 50% of psoriatic arthritis patients who used it at 6 months. Clinical responses were apparent at the time of the first visit (4 weeks) and were maintained through 6 months of therapy.

Registered nurses are available through ENBREL Support™ 7 days a week to answer patients' questions.
Our clinical experience

ENBREL has been prescribed by nearly 11,000 dermatology professionals in the US.10*

Learn more about our experience arrow

* Dermatologists, nurse practitioners, physician's assistants in dermatology offices, and dermatology subspecialists, which include D, DS, DMP, PDD, and some NP, PA, and IM/PCPs. Based on cumulative data from 2003 through May 2011.

Donna's psoriatic arthritis caused pain in many of her joints and she began to notice changes in and around her ears, fingernails, and toenails.

Donna saw a doctor and he chose ENBREL to help manage psoriatic arthritis symptoms.

"Since starting ENBREL, I've been able to get back to my daily routine."