Dosing & Injection
- How often do I need to take ENBREL?
Your doctor will tell you how often you should use ENBREL. This amount is based on the condition being treated. Do NOT use ENBREL more often than prescribed.
The recommended dose of ENBREL for adult patients with moderately to severely active rheumatoid arthritis or with ankylosing spondylitis or psoriatic arthritis is 50 mg per week. A 50-mg dose can be given as one subcutaneous injection (an injection beneath the skin) using either a 50-mg/mL Enbrel® SureClick® autoinjector or a 50-mg/mL single-use prefilled syringe. A 50-mg dose can also be given as two 25-mg subcutaneous injections using 25-mg/0.5-mL single-use prefilled syringes or 25-mg vials.
- How often does my child need to take ENBREL?
The recommended dose of ENBREL for pediatric patients ages
2 to 17 years with moderately to severely active polyarticular juvenile idiopathic arthritis is 0.8 mg/kg per week (up
to a maximum of 50 mg per week). For pediatric patients weighing 63 kg (138 pounds) or
more, the weekly dose of 50 mg may be given using Enbrel® SureClick® autoinjectors or
prefilled syringes. For pediatric patients weighing 31 kg to 62 kg (68 pounds to 136 pounds),
the total weekly dose should be given as two subcutaneous (an injection beneath the skin)
injections, either on the same day or 3 or 4 days apart. The dose for pediatric patients weighing less than 31 kg
(68 pounds) should be given as a single subcutaneous injection once weekly using the
correct volume from the 25-mg vial mixed via the free-hand method.
- Where on the body should ENBREL be injected?
On the front of the middle thighs or on the stomach, except for the 2-inch area around the belly button. These areas usually have enough tissue for the injection and are easy to reach. If a parent or caregiver is giving the injection, the outer area of the upper arms is another option.
Use a different site from those used the last couple of times. DO NOT inject into areas where the skin is tender, bruised, red, or hard. Avoid areas with scars or stretch marks.
If you have plaque psoriasis, you should try not to inject directly into any raised, thick, red, or scaly skin patches or lesions.
View injection demonstrations.
- Sometimes the skin around the injection site becomes red and itchy. Is this normal?
Yes, sometimes this can happen. In medical studies, some
patients experienced mild to moderate injection site reactions, usually within the first month.
Most reactions healed and patients could keep taking ENBREL. If you have any concerns, talk to
Read more about potential side effects.
- When using the 25-mg vial (where mixing the liquid and powder is required), after mixing the liquid and the powder, the solution appeared cloudy. Does this matter?
It's important to make sure the solution is clear before injecting. Before mixing, the powder should be white. After you add the liquid (diluent), the powder usually dissolves in about 10 minutes. The mixed solution should be clear and colorless. (A small amount of foam or bubbles may be present; this is normal.) Do NOT inject the solution if it is discolored, or if it contains lumps, flakes, or colored particles. If all the powder in the ENBREL vial is not dissolved or there are particles present after 10 minutes, call 1-888-4ENBREL (1-888-436-2735).
- What should I do with my needles, syringes, or autoinjectors after I inject?
You should not throw used needles or syringes into a regular garbage
can or recycling bin. Immediately after each injection, you should discard them in a puncture-resistant
container, often called a sharps disposal container, specifically designed for their disposal. These safe
containers can be purchased at your local pharmacy or are available through ENBREL Support™.
NEVER recap or reuse a needle, syringe, or an autoinjector. Keep all materials and sharps disposal containers out
of the reach of children.
- What should I do with my needle disposal container once it's full?
Once you've filled your sharps disposal container with used needles, syringes, or autoinjectors, you need to throw it out using the directions from your health care professional. For public safety reasons, containers generally require special disposal. State and local laws for disposing of needles vary from town to town. For information in your area, call 1-888-4ENBREL (1-888-436-2735).
Important: Do NOT recycle the sharps disposal container. Never put your sharps disposal container in the trash with other plastic recyclables (unless your local laws permit this). Never empty the contents of your sharps disposal container in order to reuse it.
You can also sign up for the ENBREL Sharps Mail-Back Program, which gives you a safe convenient way to dispose of your sharps materials at no cost to you. Call 1-888-4ENBREL (1-888-436-2735) to enroll.
- Can I still use ENBREL if I take it out of the refrigerator but don't use it right away?
ENBREL can stay at room temperature (between 68°F to 77°F) for up to 14 days. However, it's important to remember that once ENBREL reaches room temperature, you cannot put it back in the refrigerator.
Throw away ENBREL that has been stored at room temperature after 14 days. Mixed ENBREL powder should be used right away or kept in the refrigerator at 36°F to 46°F (2°C to 8°C) for up to 14 days.
If you have any questions about storing and using ENBREL, call us toll-free at 1-888-4ENBREL (1-888-436-2735).
Learn more about traveling with and storing ENBREL.
- What should I do if the needle is bent or the autoinjector is damaged?
If a needle or an autoinjector is damaged in any way, don't try to fix it or use it. If a syringe or an autoinjector is damaged, please do NOT throw it away. Call 1-888-4ENBREL for further instructions and we will help you.
Remember to review the proper techniques for preparing ENBREL that come in each carton of ENBREL.
- How should I travel with ENBREL?
There are several options for traveling with ENBREL. 1) Keep ENBREL at room temperature (between 68°F to 77°F) for up to 14 days. But remember that once ENBREL reaches room temperature, you cannot put it back in the refrigerator. Or, 2) Keep ENBREL cool—at 36°F to 46°F (2°C to 8°C). Transport ENBREL in its original packaging, wrap it in bubble wrap, and place it in your travel cooler provided by ENBREL Support™.
- Do NOT store ENBREL in extreme heat or cold. For example, avoid storing ENBREL in your vehicle's glove box or trunk.
- Do NOT freeze.
- Do NOT shake.
- Store ENBREL in the original carton to protect from light or physical damage.
- Keep ENBREL and all medicines out of the reach of children.
Then, pack it with ice. Put a thermometer in the cooler and check it
every few hours. Add ice as necessary to keep the temperature at 36°F to 46°F
(2°C to 8°C). Some hotels may have small refrigerators. Check with the hotel before your
arrival. If you're traveling by air, please call the airline ahead of time. You can call
1-888-4ENBREL (1-888-436-2735) to get a free ENBREL travel pack.
Learn more about traveling with and storing ENBREL.
- Can I travel by air with my ENBREL needles, syringes, or autoinjectors?
Check with your airline before you travel. They will be able to tell
you whether you may carry needles, syringes, or autoinjectors onto the airplane.
It is also a good idea to carry medical documentation to present to airport security. Notify
the screener if you are carrying a sharps disposal container in your carry-on baggage.
Learn more about storing and traveling with ENBREL.
- Is there any latex content in the Enbrel® (etanercept) SureClick® autoinjector or the prefilled syringes and their components?
Yes, the needle cover on the Enbrel® SureClick® autoinjector and the prefilled syringes is composed of dry natural rubber (derivative of latex), which should not be handled by persons sensitive to latex.
- What should I do if I'm not getting the results I expected?
It's important to talk to your doctor about your results and expectations for your treatment.